Although they are cousins by blood, Anju and Sudha are as close as sisters, sharing their dreams, fears, and secrets while growing up under the guidance of their mothers. As they reach adulthood, family expectations, arranged marriages, personal ambitions, and hidden family secrets begin to pull them in different directions. Despite the physical and emotional distance between them, their love and loyalty are repeatedly tested by life's hardships.

Rich in Indian culture, mythology, and emotion, Sister of My Heart explores themes of family, friendship, womanhood, identity, love, sacrifice, and resilience. Divakaruni's lyrical prose and deeply drawn characters make it a moving and memorable read.