Chapterhouse: Dune by Frank Herbert is the sixth and final novel in the original Dune Chronicles. The novel follows the Bene Gesserit as they struggle to survive the growing threat of the Honored Matres, a powerful and violent force returning from the Scattering. With their original stronghold under threat, the Bene Gesserit transform the planet Chapterhouse into a new version of Arrakis, attempting to create sandworms and restore the spice cycle. Mother Superior Darwi Odrade leads a complex strategy involving politics, genetic manipulation, religious influence, and military preparation while confronting internal conflicts within the Bene Gesserit. The novel explores power, survival, evolution, ecology, identity, religion, sexuality, leadership, and the uncertain future of humanity, bringing Herbert's original Dune saga to an unresolved and thought-provoking conclusion.