Billy Connolly's Route 66 is a travel memoir by Scottish comedian and broadcaster Billy Connolly that follows his journey along the legendary Route 66, from Chicago to Santa Monica, covering all 2,278 miles of America's most iconic highway. The book is based on his successful 2011 television documentary series and combines travel, humor, history, and personal reflections into an entertaining road-trip narrative.

Throughout the journey, Connolly visits famous landmarks such as the Gateway Arch, Grand Canyon, Monument Valley, and countless classic diners, motels, and roadside attractions that define the spirit of Route 66. More importantly, he spends time with the people who live along the highway, sharing their stories with his trademark wit, curiosity, and warmth. The book paints a vivid picture of modern America while celebrating the nostalgia and history of the "Mother Road."

Unlike traditional travel guides, this book focuses more on Connolly's personality than on practical travel information. His humorous observations, candid opinions, and spontaneous storytelling make the journey enjoyable, though readers looking for an in-depth guide to Route 66 may find it less comprehensive. Several reviewers have noted that the television series is stronger than the book because of its stunning visuals and tighter storytelling.